Publications | Tsanov Lab

Selected Publications:

Tsanov KM, Barriga FM, Ho YJ, Alonso-Curbelo D, Livshits G, Koche RP, Baslan T, Simon J, Tian S, Wuest AN, Luan W, Wilkinson JE, Masilionis I, Dimitrova N, Iacobuzio-Donahue C, Chaligné R, Pe’er D, Massagué J, Lowe SW. Metastatic site influences driver gene function in pancreatic cancer. In Revision. bioRxiv preprint: https://doi.org/10.1101/2024.03.17.585402. PMID: 38562717.

Leibold J*^,^†, Tsanov KM*, Amor C*, Ho YJ, Sánchez-Rivera FJ, Feucht J, Baslan T, Chen HA, Zamechek L, Tian S, Wilkinson JE, Lowe SW^†. (2024). Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease. Nature Cancer 5(2):315-329. PMID: 38177458.

Barriga FM*, Tsanov KM*, Ho YJ, Sohail N, Zhang A, Baslan T, Wuest AN, Del Priore I, Meškauskaitė B, Livshits G, Alonso-Curbelo D, Simon J, Chaves-Perez A, Bar-Sagi D, Iacobuzio-Donahue CA, Notta F, Sharma R, Chaligne R, Pe’er D, Lowe SW. (2022). MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis. Nature Cancer 3(11): 1367-1385. PMID: 36344707.

All Publications:

Zhao X*, Liu B*, William WN, Tsanov KM, Ho YJ, Barriga FM, Lim RJ, Trifas M, Du Y, Lowe SW**, Dubinett SM**, Davoli T**, Lippman SM**^#. Interferon-ε loss is elusive 9p21 link to immune-cold tumors, resistant to immune-checkpoint therapy and endogenous CXCL9/10 induction. (2024). J Thorac Oncol. Dec 24:S1556-0864(24)02539-5 (in press). PMID: 39725169.

Sun S*^†, You E*, Hong J, Hoyos D, Del Priore I, Tsanov KM, Mattagajasingh O, Di Gioacchino A, Marhon S, Chacon-Barahona J, Li H, Jiang H, Hozeifi S, Rosas-Bringas O, Xu KH, Song Y, Lang ER, Rojas AS, Nieman LT, Patel B, Murali R, Chanda P, Karacay A, Vabret N, De Carvalho DD, Zenklusen D, LaCava J**, Lowe SW**, Ting DT**, Iacobuzio-Donahue CA**, Solovyov A**, Greenbaum BD**^†. (2024). Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms. Immunity 57(12):2879-2894.e11. PMID: 39577413.

Leibold J*^,†, Tsanov KM*, Amor C*, Ho YJ, Sánchez-Rivera FJ, Feucht J, Baslan T, Chen HA, Zamechek L, Tian S, Wilkinson JE, Lowe SW^†. (2024). Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease. Nature Cancer 5(2):315-329. PMID: 38177458.

Schwörer S, Cimino FV, Ros R, Tsanov KM, Ng C, Lowe SW, Carmona-Fontaine C, Thompson CB. (2023). Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines. Cancer Res. 83(10):1596-1610. PMID: 36912618.

Barriga FM*, Tsanov KM*, Ho YJ, Sohail N, Zhang A, Baslan T, Wuest AN, Del Priore I, Meškauskaitė B, Livshits G, Alonso-Curbelo D, Simon J, Chaves-Perez A, Bar-Sagi D, Iacobuzio-Donahue CA, Notta F, Sharma R, Chaligne R, Pe’er D, Lowe SW. (2022). MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis. Nature Cancer 3(11): 1367-1385. PMID: 36344707.

Baslan T*, Morris IV JPM*, Zhao Z*, Reyes J, Ho YJ, Tsanov KM, Bermeo J, Tian S, Zhang S, Askan G, Yavas A, Lecomte N, Erakky A, Varghese AM, Zhang A, Kendall J, Ghiban E, Chorbadjiev L, Wu J, Dimitrova N, Chadalavada K, Nanjangud GJ, Bandlamudi C, Gong Y, Donoghue MTA, Socci ND, Krasnitz A, Notta F, Leach SD, Iacobuzio-Donahue CA, Lowe SW. (2022). Ordered and deterministic cancer genome evolution after p53 loss. Nature 608(7924): 795-802. PMID: 35978189.

Sanchez-Rivera FJ*, Diaz BJ*, Kastenhuber ER*, Schmidt H, Katti A, Kennedy M, Tem V, Ho YJ, Leibold J, Paffenholz SV, Barriga FM, Chu K, Goswami S, Wuest AN, Simon JM, Tsanov KM, Chakravaty D, Zhang H, Leslie CS, Lowe SW, Dow LE. (2022). Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nat Biotechnol. 40(6): 862-873. PMID: 35165384.

Missios P, da Rocha EL, Pearson DS, Philipp J, Aleman M, Pirouz M, Farache D, Franses JW, Kubaczka C, Tsanov KM, Jha DK, Pepe-Mooney BJ, Powers JT, Gregory RI, Lee ASY, Dominguez D, Ting DT, Daley GQ. (2021). LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy. J Clin Invest. 131(22): e145142. PMID: 34779407.

Osborne JK, Kinney MA, Han A, Akinnola KE, Yermalovich AV, Vo LT, Pearson DS, Sousa PM, Ratanasirintrawoot S, Tsanov KM, Barragan J, North TE, Metzger RJ, Daley GQ. (2021). Lin28 paralogs regulate lung branching morphogenesis. Cell Rep. 36(3): 109408. PMID: 34289374.

Alonso-Curbelo D, Ho YJ, Burdziak C, Maag JLV, Morris IV JP, Chandwani R, Chen HA, Tsanov KM, Barriga FM, Luan W, Tasdemir N, Livshits G, Azizi E, Chun J, Wilkinson JE, Mazutis L, Leach SD, Koche R, Pe’er D, Lowe SW. (2021). A gene–environment-induced epigenetic program initiates tumorigenesis. Nature 590(7847): 642-648. PMID: 33536616.

Leibold J*, Ruscetti M*, Cao Z*, Ho YJ, Baslan T, Zou M, Abida W, Feucht J, Han T, Barriga FM, Tsanov KM, Zamechek L, Kulick A, Amor C, Tian S, Rybczyk K, Salgado NR, Sanchez-Rivera FJ, Watson PA, de Stanchina E, Wilkinson JE, Dow LE, Abate-Shen C, Sawyers CL, Lowe SW. (2020). Somatic tissue engineering in mouse models reveals an actionable role for WNT pathway alterations in prostate cancer metastasis. Cancer Discov. 10(7): 1038-1057. PMID: 32376773.

Cesana M*, Guo MH*, Cacchiarelli D*, Wahlster L, Barragan J, Doulatov S, Vo LT, Salvatori B, Trapnell C, Clement K, Cahan P, Tsanov KM, Sousa P, Tazon-Vega B, Bolondi A, Giorgi FM, Califano A, Rinn JL, Meissner A, Hirschhorn JN, Daley GQ. (2018). Alternative splicing of HMGA2 by CLK3 influences human hematopoietic stem cell properties across developmental stages. Cell Stem Cell 22(4): 575-588.e7. PMID: 29625070.

Tsanov KM, Daley GQ. (2017). Signaling through RNA-binding proteins as a cell fate regulatory mechanism. Cell Cycle 16(8): 723-724. PMID: 28272977.

Tsanov KM, Pearson DS, Wu Z, Han A, Triboulet R, Seligson MT, Powers JT, Osborne JK, Kane S, Gygi SP, Gregory RI, Daley GQ. (2017). LIN28 phosphorylation by MAPK/ERK couples signaling to the post-transcriptional control of pluripotency. Nat Cell Biol. 19(1): 60-67. PMID: 27992407.

Powers JT, Tsanov KM, Pearson DS, Roels F, Spina CS, Ebright R, Seligson MT, de Soysa TY, Cahan P, Theissen J, LaPier GS, Osborne JK, Ross SJ, Cesana M, Collins JJ, Berthold F, Daley GQ. (2016). Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Nature 535(7611): 246-251. PMID: 27383785.

Shyh-Chang N*, Zhu H*, de Soysa TY, Shinoda G, Seligson MT, Tsanov KM, Asara J, Cantley LC, Daley GQ. (2013). Lin28 promotes mammalian tissue repair by reprogramming metabolism. Cell 155(4): 778-792. PMID: 24209617.

Tsanov KM, Nishi Y, Peterson KA, Liu J, Baetscher M, McMahon AP. (2012). An embryonic stem cell based system for rapid analysis of transcriptional enhancers. Genesis 50(5): 443-450. PMID: 22083581.